Bochkina G I, Sukhova G S, Udel'nov M G, Kurella G A
Biull Eksp Biol Med. 1981 Mar;91(3):259-60.
A study was made of the action of iontophoretic application of acetylcholine to the limited number of pacemaker cells with a simultaneous recording of the activity of one of them. It was shown that both generalized and strictly localized action of acetylcholine is capable of exerting different chronotropic effects. Acceleration of the rhythm was normally accompanied by an increase in the rate of accretion of slow diastolic depolarization (SDD) and by a decrease in the action potential. The same pacemaker cell was demonstrated to modulate the direction of the chronotropic reaction for an opposite one depending on acetyl-choline concentration. Low concentration of the mediator induced rhythm acceleration and an increase in the accretion rate of SDD whereas high concentration led to rhythm deceleration and SDD lowering.
研究了向有限数量的起搏细胞进行乙酰胆碱离子电渗给药的作用，并同时记录其中一个细胞的活性。结果表明，乙酰胆碱的全身性和严格局限性作用均能产生不同的变时效应。节律加快通常伴随着缓慢舒张期去极化（SDD）积累速率的增加以及动作电位的降低。同一起搏细胞被证明可根据乙酰胆碱浓度将变时反应的方向调节为相反方向。低浓度的介质诱导节律加快和SDD积累速率增加，而高浓度则导致节律减慢和SDD降低。
