急性淋巴细胞白血病及其他疾病患儿骨髓培养中前B细胞的生长情况。
Growth of pre-B cells in cultures of bone marrow from children with acute lymphoblastic leukaemia and other diseases.
作者信息
Paolucci P, Rapson N T, Layward L, Hayward A R
出版信息
Clin Exp Immunol. 1981 Jan;43(1):143-8.
Pre-B cells from the bone marrow of children with acute lymphoblastic leukaemia (ALL) survived up to 144 hr after the completion of treatment and divided in culture with maximum cell numbers at 24 hr. There was no rise in B cell number and no evidence of differentiation from pre-B to B cells. Binucleated pre-B cells in cultures containing cytochalasin B confirmed that pre-B cell division was occurring. Cycloheximide reduced cell numbers in culture but bromodeoxyuridine did not. Pre-B cell numbers also increased in culture of morphologically normal marrows from treated and untreated patients with solid tumours, and probably in normal marrows from patients with non-malignant diseases.
急性淋巴细胞白血病（ALL）患儿骨髓中的前B细胞在治疗结束后存活长达144小时，并在培养中于24小时达到最大细胞数进行分裂。B细胞数量没有增加，也没有从前B细胞分化为B细胞的证据。在含有细胞松弛素B的培养物中，双核前B细胞证实了前B细胞正在发生分裂。放线菌酮减少了培养中的细胞数量，但溴脱氧尿苷没有。在实体瘤患者经治疗和未经治疗的形态正常的骨髓培养物中，前B细胞数量也增加了，在非恶性疾病患者的正常骨髓中可能也会增加。
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