Cooper M D
J Clin Immunol. 1981 Apr;1(2):81-9. doi: 10.1007/BF00915383.
The immediate precursors of B lymphocytes have been recently identified in fetal liver and in bone marrow. Immunoglobulin genes, first of the heavy-chain gene family and later from one of the light-chain gene families, are selected and undergo functional rearrangements on one of each chromosomal pair during this stage of differentiation. Thus clonal diversity is generated among cycling pre-B cells that lack the surface antibody expression which characterizes their B-cell progeny. While the number of discriminating markers for pre-B cells is still limited, examination of bone marrow pre-B cells containing cytoplasmic mu chains but lacking surface immunoglobulin has already revealed an informative spectrum of early differentiation defects in antibody deficiency diseases and malignancies of B lineage.
B淋巴细胞的直接前体最近已在胎儿肝脏和骨髓中被鉴定出来。在这个分化阶段，免疫球蛋白基因，首先是重链基因家族的基因，随后是轻链基因家族中的一个基因，在每对染色体中的一条上被选择并经历功能重排。因此，在缺乏其B细胞后代所特有的表面抗体表达的循环前B细胞中产生了克隆多样性。虽然前B细胞的鉴别标志物数量仍然有限，但对含有细胞质μ链但缺乏表面免疫球蛋白的骨髓前B细胞的检查已经揭示了B系抗体缺乏疾病和恶性肿瘤中早期分化缺陷的信息谱。
