Gasset A R, Hinson W A, Frias J L
Ann Ophthalmol. 1978 Aug;10(8):991-4.
In a survey of 162 keratoconus patients, we set out to investigate individual conditions, such as asthma, hay fever, connective tissue syndromes, and eye rubbing, and to determine their relationship of keratoconus. It was found that the prevalence of asthma rises from 0.4% to 1% in the control group to 17.9% in the keratoconus group, or an eighteenfold increase. In addition, the incidence of hay fever in keratoconus patients was found to be 35.7%. As multifactorial disorders, keratoconus and asthma may share some of the multiple genes necessary for the expression of the disorder. Previous findings of excessive eye rubbing in keratoconus patients were confirmed in this study. Finally, we found that the incidence of connective tissue disorders associated with keratoconus was negligible.
在一项对162名圆锥角膜患者的调查中，我们着手研究个体情况，如哮喘、花粉症、结缔组织综合征和揉眼情况，并确定它们与圆锥角膜的关系。结果发现，哮喘的患病率在对照组中从0.4%升至1%，而在圆锥角膜组中则升至17.9%，增长了18倍。此外，圆锥角膜患者中花粉症的发病率为35.7%。作为多因素疾病，圆锥角膜和哮喘可能共享该疾病表达所需的一些多个基因。本研究证实了先前关于圆锥角膜患者过度揉眼的发现。最后，我们发现与圆锥角膜相关的结缔组织疾病的发病率可忽略不计。
