[Immunological, cytochemical and cytological study of lymphocytes in neoplastic and hypoplastic states of hemopoiesis].

The T and B lymphocytes, their semiquantitative cytochemistry and the nuclei were investigated in human acute and chronic leukaemia (All, CLL) and hypoplastic anaemia (HA), as well as in mice with chronic benzene poisoning (CBI). In the acute phase of ALL T and B markers were absent. In all phases, including remission, cytochemical changes and changes in the structure of nucleoli were present. In CLL, two variants of immunological alterations were found, a B cell variant and a mixed B-T cell variant. Immunological and cytochemical changes in HA and CBI were identical and this allowed to conclude that CBI is an adequate model of certain variants of human HA. The immunological and cytochemical changes in CLL, HA and CBI affected both T and B cells.