Adair H M
Ann R Coll Surg Engl. 1978 Sep;60(5):393-8.
The process of ulcer healing is still incompletely understood and the cause of delayed healing in chronic ulcers is unknown. The work described here is concerned with certain aspects of epithelial repair in experimental ulcers--that is, mitotic activity, cell migration, and cell re-establishment with differentiation, using light and electron microscopy. The findings have been compared with similar observations on human gastric and venous ulcers. The results have shown that increased mitotic activity and attempted cell migration are able to persist throughout epithelialisation of experimental lesions and that the chronicity of human ulcers cannot be explained by a lack of new epthelial cell production or failure of these cells to assume a migratory form. Some other basic defect in the healing process must therefore be present.
溃疡愈合的过程仍未被完全理解，慢性溃疡延迟愈合的原因也尚不清楚。本文所述的工作涉及实验性溃疡上皮修复的某些方面——即有丝分裂活性、细胞迁移以及细胞通过分化重新建立，采用了光学显微镜和电子显微镜技术。研究结果已与人类胃溃疡和静脉溃疡的类似观察结果进行了比较。结果表明，有丝分裂活性的增加和细胞迁移的尝试能够在实验性损伤的上皮形成过程中持续存在，而且人类溃疡的慢性不能用新上皮细胞产生不足或这些细胞无法呈现迁移形态来解释。因此，愈合过程中必定存在其他一些基本缺陷。
