Adair H M
Br J Exp Pathol. 1978 Jun;59(3):229-36.
Features of epithelial repair, namely mitotic activity, cell migration, and cell differentiation have been investigated in 17 mucosal biopsy samples from the edges of chronic gastric ulcers in 16 patients, using light and electron microscopy. Results have shown that mitosis persists at the margins of these lesions and that mitotic figures are significantly more numerous in the region of chronic ulcers than in normal mucosa. Cells with the ultrastructural features of migratory cells are present but adjacent epithelium shows abnormalities of differentiation. Lack of cell production does not appear to be the limiting factor in epithelialization and some other cause such as an abnormality of cell or re-establishment must be sought.
利用光学显微镜和电子显微镜，对16例慢性胃溃疡边缘的17份黏膜活检样本的上皮修复特征，即有丝分裂活性、细胞迁移和细胞分化进行了研究。结果显示，这些病变边缘存在有丝分裂，且慢性溃疡区域的有丝分裂象明显多于正常黏膜。具有迁移细胞超微结构特征的细胞存在，但相邻上皮显示分化异常。细胞增殖不足似乎不是上皮形成的限制因素，必须寻找其他原因，如细胞异常或重新建立异常。
