一个与免疫球蛋白重链恒定区（Igh-C）基因座相关的基因控制着小鼠体内类风湿因子的产生。
A gene linked to the Igh-C locus controls the production of rheumatoid factor in the mouse.
作者信息
Van Snick J L
出版信息
J Exp Med. 1981 Mar 1;153(3):738-42. doi: 10.1084/jem.153.3.738.
In certain specific pathogen-free colonies, mice, upon aging, produce autoantibodies (RF) specific for the Fc portion of their IgG. In our colony, 129/Sv mice (H-2bvl; Igh-1a) have 10-20 times higher RF levels than C5BL/6 (h-2b; Igh-1b). In addition, the 129 have mainly IgA anti-IgG2a, and the B6 have mainly IgM anti-IgGl. We analyzed the genetic factors that control these differences. The high RF-producer phenotype of strain 129 was inherited as a recessive trait as indicated by the low RF levels of (129 X B6) F1 mice. About 1 of 4 129 X F1 (129 X B6) backcrosses and 1 of 10 (129 X B6) F2 mice had high RF levels, suggesting the involvement of two recessive genes in the control of this RF production. All F2 mice and all but one backcross with high IgA anti-IgG2a levels were homozygous for the Ihg-1a allele of the 129 mouse. In contrast, the B6-type RF was eight times more frequent in Igh-1bb than in Igh-1ab or Igh-1aa mice. High RF titers of either type were suppressed in Igh-1ab mice.
在某些特定的无病原体群体中，小鼠随着年龄增长会产生针对其IgG Fc部分的自身抗体（RF）。在我们的群体中，129/Sv小鼠（H-2bvl；Igh-1a）的RF水平比C5BL/6（h-2b；Igh-1b）高10到20倍。此外，129小鼠主要产生IgA抗IgG2a，而B6小鼠主要产生IgM抗IgG1。我们分析了控制这些差异的遗传因素。如（129×B6）F1小鼠的低RF水平所示，129品系的高RF产生者表型作为隐性性状遗传。约四分之一的129×F1（129×B6）回交小鼠和十分之一的（129×B6）F2小鼠具有高RF水平，这表明有两个隐性基因参与了这种RF产生的控制。所有F2小鼠以及除一只外所有具有高IgA抗IgG2a水平的回交小鼠对于129小鼠的Ihg-1a等位基因都是纯合的。相比之下，Igh-1bb小鼠中B6型RF的出现频率比Igh-1ab或Igh-1aa小鼠高八倍。Igh-1ab小鼠中两种类型的高RF滴度均受到抑制。
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