小鼠中针对甲状腺球蛋白的IgG2a抗体反应与免疫球蛋白重链基因座相关。
The IgG2a antibody response to thyroglobulin is linked to the Igh locus in mouse.
作者信息
Kuppers R C, Epstein L D, Outschoorn I M, Rose N R
机构信息
Department of Immunology and Infectious Disease, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205.
出版信息
Immunogenetics. 1994;39(6):404-11. doi: 10.1007/BF00176157.
The IgG-subclass usage by several strains of mice in the response to immunization with mouse thyroglobulin (mTg) was examined in the experimental autoimmune thyroiditis model. While the subclass usage by most mouse strains was similar, the Ighb allotype-bearing mice consistently produced lower IgG2a levels to mTg. Using CBA-Ighb congenic and recombinant inbred strains of mice, the lower level of IgG2a in the Ighb mouse was mapped to the Igh locus. The regulation of IgG2a appeared to be cis controlled, as the CBA x C57BL/6F1 mouse also produced reduced IgG2a of the Ighb (B6) allotype but not of the Ighj (CBA) allotype.
在实验性自身免疫性甲状腺炎模型中，研究了几种品系小鼠在对小鼠甲状腺球蛋白（mTg）免疫应答时的IgG亚类使用情况。虽然大多数小鼠品系的亚类使用情况相似，但携带Ighb同种异型的小鼠对mTg产生的IgG2a水平始终较低。利用CBA-Ighb同源基因小鼠和重组近交系小鼠，将Ighb小鼠中较低水平的IgG2a定位到Igh基因座。IgG2a的调节似乎是顺式控制的，因为CBA×C57BL/6F1小鼠也产生了降低的Ighb（B6）同种异型的IgG2a，但没有降低Ighj（CBA）同种异型的IgG2a。
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