PiPclifton: a new alpha 1-antitrypsin allele in an American Negro family.

Serum specimens from eight females and two males representing three generations of an American Negro family exhibited an α-antitrypsin phenotype that we labelled MPclifton because of its electrophoretic mobility. The family study and examination of multiple specimens from the same subject indicated that the phenotype represented an α-antitrypsin allele, labelled Pi. The new genetic variant is not associated with deficiency of α-antitrypsin or of trypsin inhibitory capacity in the serum.