血小板再生时间与主动脉冠状动脉大隐静脉旁路移植血管的晚期闭塞
Platelet regeneration time and late occlusion of aortocoronary saphenous vein bypass grafts.
作者信息
Latour J G, Trudel J R, Campeau L, Côté P, Bourassa M G, Corbara F, Solymoss C B
出版信息
Can Med Assoc J. 1980 Jun 21;122(12):1390-3.
The half-time for platelet regeneration was estimated in 16 patients with aortocoronary vein grafts by the use of a non-radioisotopic technique based on the permanent inhibition by acetylsalicylic acid of lipid peroxidation by platelets. Ten patients had patent grafts after 6 years; in the other six at least one graft had become occluded between 2 and 6 years after the operation as shown by serial angiography. The mean half-time (+/- the standard error) for platelet regeneration was reduced to 2.5 +/- 0.2 days (P less than 0.002) in the group with occluded grafts as compared with 3.3 +/- 11 healthy volunteers. These results suggest a relation between late graft occlusion and platelet turnover and support the idea that patients with aortocoronary vein grafts could benefit from platelet suppressive therapy. Finally, the method employed appears to be a useful and simple way of evaluating platelet function in vivo.
通过使用一种基于阿司匹林对血小板脂质过氧化的永久性抑制作用的非放射性同位素技术，对16例接受主动脉冠状动脉静脉搭桥术的患者进行了血小板再生半衰期的评估。6年后，10例患者的移植血管通畅；另外6例患者，根据系列血管造影显示，术后2至6年间至少有一根移植血管发生了闭塞。与11名健康志愿者相比，移植血管闭塞组的血小板再生平均半衰期（±标准误）缩短至2.5±0.2天（P<0.002），而健康志愿者的为3.3± 。这些结果提示晚期移植血管闭塞与血小板更新之间存在关联，并支持接受主动脉冠状动脉静脉搭桥术的患者可从血小板抑制治疗中获益这一观点。最后，所采用的方法似乎是一种评估体内血小板功能的有用且简便的方法。
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