[青少年类风湿性关节炎与人类白细胞抗原B27]
[Juvenile rheumatoid arthritis and HLA-B27].
作者信息
Mathon G, Paré C, Ménard H, Tétreault L, Camerlain M
出版信息
Can Med Assoc J. 1980 Sep 6;123(5):377-9.
Forty children with juvenile rheumatoid arthritis were studied to determine the frequency of the histocompatibility antigen HLA [human leukocyte antigen)-B27 in this disease and to characterize the arthropathy associated with this antigen. HLA-B27 was detected in four patients (10%). Its presence was associated in a statistically significant manner with sacroiliitis demonstrated radiologically and with a greater age at the time symptoms in the joints first appeared; this age was, on average, 10 years, compared with 6.29 years for the children without HLA-B27.
对40名青少年类风湿性关节炎患儿进行了研究，以确定组织相容性抗原HLA（人类白细胞抗原）-B27在该疾病中的出现频率，并对与该抗原相关的关节病进行特征描述。在4名患者（10%）中检测到HLA-B27。其存在与放射学显示的骶髂关节炎以及关节症状首次出现时的年龄较大存在统计学上的显著关联；有HLA-B27的患儿症状首次出现时的平均年龄为10岁，而无HLA-B27的患儿为6.29岁。
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