Kravchenko L S, Nesterova L A, Glubokovskaia O I, Tereshin I M
Antibiotiki. 1978 Sep;23(9):823-9.
Activity of Na+, K+-ATP- ase and 5'-nucleotidase, the lipid composition of the liver plasmic membranes with toxic and alimentary-alcohol fat dystrophy were studied on rats exposed to water-soluble sodium levorin. It was found that the above forms of the liver fat dystrophy did not change the activity of the enzymes in the membranes but caused significant shifts in the composition of the membrane lipids. The shifts were evident from an increased level of phospholipids in the plasmic membranes. Administration of levorin at the very beginning of the development of both the toxic and the alimentary-alcohol liver fat dystrophy aggravated the increase in the phospholipid level in the membranes. It was supposed that the increase in the phospholipid level due to levorin in the membranes of the liver with fat dystrophy was one of the mechanisms of the drug therapeutic effect in case of such pathology type. Levorin increased the amount of phospholipids in the dystrophic membranes and thus changed the membrane permeability resulting in decreased accumulation of neutral lipids in the hepacytes and subsequently in decreased levels of the liver fat dystrophy.
对暴露于水溶性左洛啡的大鼠，研究了其在有毒性和营养性酒精性脂肪营养不良情况下肝质膜中钠钾ATP酶和5'-核苷酸酶的活性以及脂质组成。结果发现，上述肝脂肪营养不良形式并未改变膜中酶的活性，但导致膜脂质组成发生显著变化。这种变化从质膜中磷脂水平升高明显可见。在毒性和营养性酒精性肝脂肪营养不良发展初期给予左洛啡，会加重膜中磷脂水平的升高。据推测，左洛啡导致脂肪营养不良肝脏膜中磷脂水平升高是该药对这类病理情况发挥治疗作用的机制之一。左洛啡增加了营养不良膜中磷脂的含量，从而改变了膜通透性，导致肝细胞中中性脂质积累减少，进而降低了肝脂肪营养不良的程度。
