Titov A V, Tarasova O V, Slobodskaia V V, Vavilin G I
Antibiotiki. 1982 Dec;27(12):42-6.
The effect of the sodium salts of levorin, isolevorin, nystatin and amphotericin B prepared with the use of sodium desoxycholate and amphoglucamine on the development of fatty degeneration of the liver was studied in rats. Fatty degeneration of the liver was induced in the animals by the diet deficient in choline and administration of alcohol (10 g/kg). Most of the studied antibiotics inhibited the development of the liver fatty degeneration. The only exclusion was amphotericin B prepared with the use of sodium desoxycholate which did not influence the level of the liver fatty degeneration. Sodium levorin (10 mg/kg) produced the most pronounced normalizing effect on the lipid metabolism in the liver. Complication of mycoses with fatty degeneration of the liver should not be considered as a contraindication to their treatment with polyenic antibiotics.
研究了用去氧胆酸钠和两性霉素B制备的左菌素、异左菌素、制霉菌素和两性霉素B的钠盐对大鼠肝脏脂肪变性发展的影响。通过胆碱缺乏饮食和给予酒精（10克/千克）诱导动物发生肝脏脂肪变性。大多数研究的抗生素抑制了肝脏脂肪变性的发展。唯一的例外是用去氧胆酸钠制备的两性霉素B，它对肝脏脂肪变性水平没有影响。左菌素钠（10毫克/千克）对肝脏脂质代谢产生了最明显的正常化作用。真菌病合并肝脏脂肪变性不应被视为用多烯抗生素治疗它们的禁忌症。
