Konaka Y, Norcross M A, Maino V C, Smith R T
Eur J Immunol. 1981 Jun;11(6):445-50. doi: 10.1002/eji.1830110602.
Rabbit anti-Thy-1 antibody bound to T cells induces the appearance of T cell growth factor (interleukin 2, IL2) receptors and the production of IL2. IL2 receptors induction by this means occurs within a short time span, and independent of any demonstrable accessory cell. A source of exogenous or endogenous IL2 is apparently the only requirement for proliferation after these receptors are expressed. IL2 production, on the other hand, is accessory cell-dependent, and this help is mediated via Fc receptors on the accessory cell. IL2 production in this model is demonstrable at 4-6 h, or earlier, and is proliferation-independent. X-irradiation actually augments apparent IL2 production. The data are consistent with the hypothesis that a differentiated subset of T cells in any mixed population is responsible for IL2 production.
与T细胞结合的兔抗Thy-1抗体可诱导T细胞生长因子（白细胞介素2，IL2）受体的出现并促使IL2的产生。通过这种方式诱导IL2受体的出现发生在短时间内，且不依赖于任何可证实的辅助细胞。在这些受体表达后，外源性或内源性IL2的来源显然是增殖的唯一必要条件。另一方面，IL2的产生依赖于辅助细胞，这种帮助是通过辅助细胞上的Fc受体介导的。在该模型中，IL2的产生在4 - 6小时或更早时即可检测到，且与增殖无关。X射线照射实际上会增加明显的IL2产生。这些数据与以下假设一致，即任何混合群体中T细胞的一个分化亚群负责IL2的产生。
