两性霉素B所致贫血中的促红细胞生成素浓度
Erythropoietin concentration in amphotericin B-induced anemia.
作者信息
MacGregor R R, Bennett J E, Erslev A J
出版信息
Antimicrob Agents Chemother. 1978 Aug;14(2):270-3. doi: 10.1128/AAC.14.2.270.
Abstract
Amphotericin B was given to six patients with systemic fungal infections. A dose averaging 1.78 g, administered from 42 to 144 days, was associated with a fall in hematocrit to a mean value of 25.8%. Despite this degree of anemia, no elevation of erythropoietin concentrations in urine or serum could be detected. Thus, amphotericin appears to cause anemia by inhibiting erythropoietin production rather than by suppressing bone marrow activity directly.
摘要
两性霉素B用于6例全身性真菌感染患者。平均剂量为1.78g，给药时间为42至144天，用药后血细胞比容降至平均25.8%。尽管出现了这种程度的贫血，但未检测到尿液或血清中促红细胞生成素浓度升高。因此，两性霉素似乎是通过抑制促红细胞生成素的产生而非直接抑制骨髓活性来导致贫血的。
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