Lochmann E R, Käufer N, Schütze S, Kreutzfeldt C
Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Jul;40(1):1-9.
The effect of photodynamic treatment with thiopyronine and visible light on RNA metabolism in yeast cells was investigated at different times during logarithmic growth. The results show that RNA synthesis in the nucleus of the cells is not directly inhibited photodynamically. In the endoplasmic reticulum of photodynamically treated cells one finds mRNA in about the same relative amounts and quality as in untreated control cells, but the binding of polysomes on membranes in the cytoplasm as the first step of protein synthesis is inhibited for a long time after treatment as well as the synthesis of ribosomes.
在对数生长期的不同时间，研究了硫代吡咯宁和可见光光动力处理对酵母细胞RNA代谢的影响。结果表明，细胞细胞核中的RNA合成并未受到光动力直接抑制。在经光动力处理的细胞内质网中，发现mRNA的相对含量和质量与未处理的对照细胞大致相同，但处理后很长一段时间内，作为蛋白质合成第一步的多核糖体在细胞质膜上的结合以及核糖体的合成均受到抑制。
