Pap T, Retih I, Kajtár P
Morphol Igazsagugyi Orv Sz. 1980 Apr;20(2):123-9.
In 9 children out of 36 with ALL examined post mortem at the Department of Pathology of the Medical University of Pécs in the period 1960--1978 leukaemic infiltrates were not found at all ("total remission"). 7 cases out of the 9 observed during the last 5 years. The remaining 27 cases could be divided into two groups: at 20 children nuclei of the leukaemic cells have shown marked gyrification. Survival of children of this group was 10.8 months. At the remaining 7 children the surface of the cell nuclei appeared to be smooth. The survival in this group was 3.6 months. These data support the hypothesis according to which ALL of the children and T cell malignant lymphomas may be of two types. Those with gyrificated and with non-gyrificated nuclei. The considerable difference in survival of patients with these two types of leukaemia suggests that the morphology of the cell nuclei i.e. "gyrification" or "non-gyrification" of them may be used in estimation of the prognosis.
1960年至1978年间，在佩奇医科大学病理学系对36例急性淋巴细胞白血病（ALL）患儿进行尸检，其中9例未发现白血病浸润（“完全缓解”）。这9例中有7例是在过去5年中观察到的。其余27例可分为两组：20例患儿的白血病细胞核呈现明显的脑回状。该组患儿的生存期为10.8个月。其余7例患儿的细胞核表面看起来光滑。该组患儿的生存期为3.6个月。这些数据支持这样一种假说，即所有儿童急性淋巴细胞白血病和T细胞恶性淋巴瘤可能有两种类型。一种是细胞核呈脑回状的，另一种是细胞核无脑回状的。这两种类型白血病患者生存期的显著差异表明，细胞核的形态，即细胞核的“脑回状”或“无脑回状”，可用于评估预后。
