血清素在小鼠和大鼠吗啡依赖形成中的作用
Participation of serotonin in development of morphine dependence in mice and rats.
作者信息
Kruszewska A
出版信息
Pol J Pharmacol Pharm. 1980 Sep-Oct;32(5):655-63.
The effect of compounds inhibiting serotonergic transmission (reserpine, cyproheptadine, LSD) and stimulating it (imipramine, fluoxetine, 5-hydroxytryptophan) on the development of morphine dependence in mice and rats was investigated. Reserpine inhibited the development of morphine dependence in mice and rats. A combined treatment with 5-hydroxytryptophan and reserpine reversed the inhibitory action of reserpine on development of morphine dependence in mice. Cyproheptadine did not affect and LSD potentiated the formation of morphine dependence in mice. Imipramine potentiated the development of dependence in mice and rats and fluoxetine in mice. The results suggest that a decrease in the function of serotonergic system inhibits the development of morphine dependence, while stimulation of this system potentiates the development of the dependence in mice and rats. It seems that the retention of activity of presynaptic serotonin nerve endings is of importance in the development of dependence.
研究了抑制血清素能传递的化合物（利血平、赛庚啶、麦角酸二乙酰胺）和刺激血清素能传递的化合物（丙咪嗪、氟西汀、5-羟色氨酸）对小鼠和大鼠吗啡依赖形成的影响。利血平抑制小鼠和大鼠吗啡依赖的形成。5-羟色氨酸与利血平联合治疗可逆转利血平对小鼠吗啡依赖形成的抑制作用。赛庚啶对小鼠吗啡依赖形成无影响，而麦角酸二乙酰胺增强小鼠吗啡依赖的形成。丙咪嗪增强小鼠和大鼠的依赖形成，氟西汀增强小鼠的依赖形成。结果表明，血清素能系统功能降低会抑制吗啡依赖的形成，而刺激该系统则会增强小鼠和大鼠的依赖形成。似乎突触前血清素神经末梢活性的保留对依赖的形成很重要。
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