[Neuroradiological experiences iopamidol, a new non-ionic hydro-soluble contrast medium. Comparison to metrizamide with special considerations of side effects and pharmacodynamics with regard to clinical use (author's transl)].

A report is given about the non-ionic hydrosoluble contrast medium Iopamidol, which is compared to metrizamide for lumbosacral radiculography and computed tomography cisternography (CTC). The side effects are discussed. A raised attenuation value of brain parenchyma is the effect of a migration of contrast medium into extracellular space. A quantitative measurement is possible through density profiles at different times after the contrast application together with planimetry, which are characteristic for the normal and the various pathologic kinds of CSF dynamics. These results and the simultaneously registered EEG-changes are giving informations of the pathophysiology of intrathecally used contrast media. Therefore is indispensable to keep the amount of contrast substance as low as possible. The paper gives hints for the dosage.