生长调节素B：源自污染物表皮生长因子的促有丝分裂活性。
Somatomedin B: mitogenic activity derived from contaminant epidermal growth factor.
作者信息
Heldin C H, Wasteson A, Fryklund L, Westermark B
出版信息
Science. 1981 Sep 4;213(4512):1122-3. doi: 10.1126/science.6973821.
PMID:6973821
Abstract
The mitogenic effect of somatomedin B on human cultured glial cells was neutralized by the addition of antibodies to mouse epidermal growth factor. Somatomedin B contained epidermal growth factor--like activity, competing for binding to the epidermal growth factor receptor. It is concluded that contaminating epidermal growth factor may explain the entire mitogenic activity of somatomedin B.
摘要
通过添加针对小鼠表皮生长因子的抗体，可中和生长调节素B对人培养神经胶质细胞的促有丝分裂作用。生长调节素B含有表皮生长因子样活性，能竞争结合表皮生长因子受体。由此得出结论，污染的表皮生长因子可能解释生长调节素B的全部促有丝分裂活性。
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