Noguchi T, Sugiasaki T, Tsukada Y
Neurochem Res. 1985 Aug;10(8):1097-106. doi: 10.1007/BF00965884.
To determine whether GH has an independent action on cerebral development, we examined the central nervous system of the little mouse (lit), a promising model of isolated growth hormone deficiency. Our findings are (A); the weights of two parts of the lit brain were significantly less than those of the normal controls, 81.5% less for the cerebrum, and 81.6% for the cerebellum, (B): the total DNA content was reduced to approximately 80% in the cerebrum and 84% in the cerebellum compared to those of the normal controls, (C); the total RNA content was also reduced in the cerebrum and cerebellum, proportional to the reduction in DNA, (D); CNPase activity was reduced selectively in the cerebrum of the lit mouse (74.4% of the normal control), and (E); the lit mice exhibited a strikingly reduced level of activity with an indistinct diurnal periodicity. These results indicate that GH has independent actions on cerebral development, especially on glial cell proliferation as a precondition of myelin formation.
为了确定生长激素（GH）对大脑发育是否具有独立作用，我们研究了小鼠矮小症（lit）的中枢神经系统，这是一种有前景的孤立性生长激素缺乏症模型。我们的研究结果如下：（A）lit小鼠大脑两个部分的重量明显低于正常对照组，大脑重量减少81.5%，小脑重量减少81.6%；（B）与正常对照组相比，大脑总DNA含量降至约80%，小脑降至84%；（C）大脑和小脑的总RNA含量也减少，与DNA减少成比例；（D）lit小鼠大脑中2',3'-环核苷酸3'-磷酸二酯酶（CNPase）活性选择性降低（为正常对照的74.4%）；（E）lit小鼠的活动水平显著降低，昼夜节律不明显。这些结果表明，GH对大脑发育具有独立作用，尤其是对作为髓鞘形成前提条件的神经胶质细胞增殖有作用。
