• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Self-induction by triacetyloleandomycin of its own transformation into a metabolite forming a stable 456 nm-absorbing complex with cytochrome P-450.

作者信息

Pessayre D, Descatoire V, Konstantinova-Mitcheva M, Wandscheer J C, Cobert B, Level R, Benhamou P J, Jaouen M, Mansuy D

出版信息

Biochem Pharmacol. 1981 Mar 15;30(6):553-8. doi: 10.1016/0006-2952(81)90125-8.

DOI:10.1016/0006-2952(81)90125-8
PMID:6973977
Abstract
摘要

相似文献

1
Self-induction by triacetyloleandomycin of its own transformation into a metabolite forming a stable 456 nm-absorbing complex with cytochrome P-450.三乙酰竹桃霉素自身诱导其转化为一种与细胞色素P-450形成稳定的456纳米吸收复合物的代谢产物。
Biochem Pharmacol. 1981 Mar 15;30(6):553-8. doi: 10.1016/0006-2952(81)90125-8.
2
Self-induction by oleandomycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450. Comparison with troleandomycin.
J Pharmacol Exp Ther. 1982 Apr;221(1):215-21.
3
Formation of an inactive cytochrome P-450 Fe(II)-metabolite complex after administration of troleandomycin in humans.在人体中服用醋竹桃霉素后形成无活性的细胞色素P-450 Fe(II)-代谢物复合物。
Biochem Pharmacol. 1982 May 1;31(9):1699-704. doi: 10.1016/0006-2952(82)90671-2.
4
Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione.曲古霉素代谢产物对细胞色素P - 450的灭活作用。谷胱甘肽的保护作用。
J Pharmacol Exp Ther. 1983 Mar;224(3):685-91.
5
Induction of cytochrome P-450 in rat liver by the antibiotic troleandomycin: partial purificaton and properties of cytochrome P-450-troleandomycin metabolite complexes.抗生素三乙酰竹桃霉素对大鼠肝脏细胞色素P - 450的诱导作用：细胞色素P - 450 - 三乙酰竹桃霉素代谢物复合物的部分纯化及性质
Biochem Biophys Res Commun. 1981 Dec 31;103(4):1201-8. doi: 10.1016/0006-291x(81)90250-3.
6
Drug interactions with macrolide antibiotics: specificity of pseudo-suicide inhibition and induction of cytochrome P-450.
Adv Exp Med Biol. 1986;197:155-62. doi: 10.1007/978-1-4684-5134-4_12.
7
The cytochrome P-450 metabolite complex derived from troleandomycin: properties in vitro and stability in vivo.由醋竹桃霉素衍生而来的细胞色素P - 450代谢物复合物：体外特性及体内稳定性
Chem Biol Interact. 1984 Oct;51(3):371-6. doi: 10.1016/0009-2797(84)90162-5.
8
In vivo and in vitro effects of a new macrolide antibiotic roxithromycin on rat liver cytochrome P-450: comparison with troleandomycin and erythromycin.
Chem Biol Interact. 1988;68(3-4):179-88. doi: 10.1016/0009-2797(88)90015-4.
9
Dual effects of macrolide antibiotics on rat liver cytochrome P-450. Induction and formation of metabolite-complexes: a structure-activity relationship.
Biochem Pharmacol. 1983 Aug 1;32(15):2309-18. doi: 10.1016/0006-2952(83)90178-8.
10
Cytochrome P450 metabolic intermediate complexes from macrolide antibiotics and related compounds.来自大环内酯类抗生素及相关化合物的细胞色素P450代谢中间复合物。
Methods Enzymol. 1991;206:559-73. doi: 10.1016/0076-6879(91)06126-n.

引用本文的文献

1
Numerical analysis of time-dependent inhibition kinetics: comparison between rat liver microsomes and rat hepatocyte data for mechanistic model fitting.时间依赖性抑制动力学的数值分析：用于机制模型拟合的大鼠肝微粒体和大鼠肝细胞数据之间的比较。
Xenobiotica. 2020 Nov;50(11):1301-1310. doi: 10.1080/00498254.2017.1345020. Epub 2020 Aug 24.
2
Factors affecting the clinical development of cytochrome p450 3A substrates.影响细胞色素P450 3A底物临床开发的因素。
Clin Pharmacokinet. 2003;42(11):969-84. doi: 10.2165/00003088-200342110-00003.
3
Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase.
人细胞色素P450 3A4：含NADPH-P450还原酶的纯化重组融合蛋白的酶学性质
Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11748-52. doi: 10.1073/pnas.90.24.11748.
4
Clarithromycin clinical pharmacokinetics.克拉霉素的临床药代动力学。
Clin Pharmacokinet. 1993 Sep;25(3):189-204. doi: 10.2165/00003088-199325030-00003.
5
Identification of an inducible form of cytochrome P-450 in human liver.人肝脏中一种可诱导形式细胞色素P-450的鉴定。
Proc Natl Acad Sci U S A. 1985 Sep;82(18):6310-4. doi: 10.1073/pnas.82.18.6310.
6
Pharmacokinetic interactions of the macrolide antibiotics.大环内酯类抗生素的药代动力学相互作用。
Clin Pharmacokinet. 1985 Jan-Feb;10(1):63-79. doi: 10.2165/00003088-198510010-00003.
7
Interaction of carbon tetrachloride and progesterone metabolism in liver microsomes from triacetyloleandomycin-treated rats.三乙酰竹桃霉素处理的大鼠肝脏微粒体中四氯化碳与孕酮代谢的相互作用
Arch Toxicol. 1987;60(1-3):122-3. doi: 10.1007/BF00296963.
8
Troleandomycin effects on methylprednisolone and methylprednisone interconversion and disposition in the rabbit.
Eur J Drug Metab Pharmacokinet. 1987 Jan-Mar;12(1):50-7. doi: 10.1007/BF03189861.
9
Effect of miocamycin on theophylline kinetics in children.
Eur J Clin Pharmacol. 1987;31(6):701-4. doi: 10.1007/BF00541298.
10
Clinical pharmacokinetic properties of the macrolide antibiotics. Effects of age and various pathophysiological states (Part II).大环内酯类抗生素的临床药代动力学特性。年龄及各种病理生理状态的影响（第二部分）
Clin Pharmacokinet. 1989 May;16(5):261-82. doi: 10.2165/00003088-198916050-00001.