[老年大鼠及氢化可的松处理动物脾细胞的自身反应性]
[Autoreactivity of splenic cells of old rats and animals treated with hydrocortisone].
作者信息
Meĭlikhova A N, Maianskiĭ D N, Kozlov V A
出版信息
Biull Eksp Biol Med. 1981 Jun;91(6):706-7.
PMID:6974017
Abstract
Spleen cells from 14-month-old mice are capable to induce GVH reaction in syngeneic recipients. Spleen cells obtained on the third day after hydrocortisone injection also induce GVH reaction in syngeneic recipients. The results suggest that T cells which suppress the activity of autoreactive lymphocytes are eliminated with age and after exposure to hydrocortisone.
摘要
14月龄小鼠的脾细胞能够在同基因受体中诱导移植物抗宿主反应（GVH反应）。氢化可的松注射后第三天获得的脾细胞也能在同基因受体中诱导GVH反应。结果表明，抑制自身反应性淋巴细胞活性的T细胞会随着年龄增长以及在接触氢化可的松后被清除。
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