Gozes Y, Umiel T, Meshorer A, Trainin N
J Immunol. 1978 Dec;121(6):2199-204.
The frequency of autoimmune processes seems to increase with age. We have studied here whether lymphoid cells of aged mice have the potential to express autoreactivity by the use of the in vivo graft-vs-host (GvH) assay. It was found that spleen cells from old (104 weeks) C57BL mice caused significant enlargement of the popliteal lymph node upon injection into the footpads of syngeneic young or old recipients. Histologically this enlargement presented characteristics of a GvH reaction. This effect, which was not abolished by irradiation of the hosts, was totally cancelled by in vitro irradiation or by anti-theta treatment of the donor cells. These results indicate that T cells from aged mice have the potential to manifest autoimmune reactivity.
自身免疫过程的频率似乎随年龄增长而增加。我们在此研究了老年小鼠的淋巴细胞是否有通过体内移植物抗宿主（GvH）试验表达自身反应性的潜力。结果发现，将来自老年（104周）C57BL小鼠的脾细胞注射到同基因年轻或老年受体的足垫后，腘淋巴结会显著肿大。组织学上，这种肿大呈现出移植物抗宿主反应的特征。这种效应不会因宿主接受照射而消除，但通过供体细胞的体外照射或抗θ处理可完全消除。这些结果表明，老年小鼠的T细胞具有表现自身免疫反应性的潜力。
