Kovalevskiĭ G V, Skriabina G A
Biull Eksp Biol Med. 1981 Jun;91(6):727-30.
Atrophy of the thymus cortex was found in rats after administration of oxythiamine. In acute experiments, atrophy was a consequence of a short-term inhibition of proliferation followed by enhancement of disintegration of small thymocytes by caryorhexis. Disintegration assumes an exceptional significance for thymus involution. Breakdown of cells correlated with a sharp decrease in thymocyte resistance to hydrocortisone. Possible metabolic reasons for the decreased resistance are discussed.
给予硫胺素氧嘧啶后，在大鼠中发现胸腺皮质萎缩。在急性实验中，萎缩是短期增殖抑制的结果，随后小胸腺细胞通过核崩解加速解体。解体对胸腺退化具有特殊意义。细胞解体与胸腺细胞对氢化可的松的抵抗力急剧下降相关。讨论了抵抗力下降的可能代谢原因。
