Bandazhevskiĭ Iu I
Arkh Anat Gistol Embriol. 1984 Nov;87(11):88-92.
In pregnant females B1-hypovitaminosis was induced by injecting various doses of oxythiamine--a specific antimetabolite for B1 vitamin. The rat and hamster embryos were respectively treated on the 20th and 15th days of development after the technique suggested by Dauson-Dyban with staining the osseous anlages of the skeletons with alizarine red. The results of the investigations performed in 193 skeletons of the rat embryos and in 196 skeletons of the golden hamster embryos revealed a progressive decrease, as the dose of oxythiamine increased, in length of ossification anlages of the extremity bones. However, susceptibility to lesions in various bones of the extremity and skull skeletons was not similar under conditions of progressive oxythiamine-induced B1-hypovitaminosis and depended on time of their anlage formations.
在怀孕雌性动物中，通过注射不同剂量的氧硫胺素（维生素B1的一种特异性抗代谢物）诱导维生素B1缺乏症。按照道森 - 戴班提出的技术，在大鼠和仓鼠胚胎发育的第20天和第15天分别进行处理，并用茜素红对骨骼的骨原基进行染色。对193具大鼠胚胎骨骼和196具金黄仓鼠胚胎骨骼进行研究的结果显示，随着氧硫胺素剂量的增加，四肢骨骼骨化原基的长度逐渐缩短。然而，在逐渐由氧硫胺素诱导的维生素B1缺乏症的情况下，四肢和颅骨骨骼不同骨骼对损伤的易感性并不相同，这取决于它们原基形成的时间。
