Rabii J, Buonomo F, Scanes C G
J Endocrinol. 1981 Sep;90(3):355-8. doi: 10.1677/joe.0.0900355.
Plasma levels of GH and prolactin were measured by radioimmunoassay in male domestic fowl treated with centrally active agents. p-Chlorophenylalanine (pCPA) did not have an effect on tonic levels of prolactin but led to a significant rise in circulating GH concentrations. The three serotonin receptor antagonists tested, methysergide, SQ-10631 and cyproheptadine, each resulted in a significant reduction in plasma prolactin while markedly increasing plasma GH levels. Administration of 5-hydroxytryptophan led to a rise in plasma prolactin and a drop in plasma GH levels in untreated birds or in animals pretreated with pCPA. The serotonin receptor agonist, quipazine, resulted in a marked increase in plasma prolactin and a marked reduction in plasma GH concentrations in untreated birds. In pCPA-pretreated animals quipazine was no longer effective in altering plasma prolactin levels but still caused a significant drop in circulating levels of GH. These results suggest that in the young male domestic fowl serotonin has a stimulatory role in the regulation of prolactin and an inhibitory role in the regulation of GH secretion.
采用放射免疫分析法测定了经中枢活性药物处理的雄性家禽血浆中生长激素（GH）和催乳素的水平。对氯苯丙氨酸（pCPA）对催乳素的基础水平没有影响，但导致循环中GH浓度显著升高。所测试的三种5-羟色胺受体拮抗剂，即麦角新碱、SQ - 10631和赛庚啶，均导致血浆催乳素显著降低，同时显著提高血浆GH水平。给予5-羟色氨酸导致未处理的家禽或经pCPA预处理的动物血浆催乳素升高，血浆GH水平下降。5-羟色胺受体激动剂喹哌嗪导致未处理的家禽血浆催乳素显著升高，血浆GH浓度显著降低。在经pCPA预处理的动物中，喹哌嗪不再能有效改变血浆催乳素水平，但仍导致循环中GH水平显著下降。这些结果表明，在幼年雄性家禽中，5-羟色胺在催乳素调节中起刺激作用，在GH分泌调节中起抑制作用。
