Fournier M, Potworowski E F, Kowalczyk D
Immunobiology. 1981;159(4-5):382-91. doi: 10.1016/S0171-2985(81)80094-0.
The evolution of T-cell subsets in the thymuses of leukemia-prone AKR mice and of non-leukemia-prone BALB/c mice was compared for a period of 9 months. In AKR mice there is a sharp rise in thymic hormone sensitive thymocytes bearing a high concentration of Thy 1 antigen. While these cells also rise with age in BALB/c mice, they do so more slowly. The response of thymocytes to Con A was also compared between the two strains: the response of AKR cells drops to below significant levels within seven months, while BALB/c cells remain reactive throughout the experimental period. Since these age-related changes in Thy 1 antigen density and Con A reactivity can be reversed after incubation with a thymic hormone preparation, it is concluded that they are the result of a decrease in thymic hormone secretion, that this decrease is much more pronounced in AKR mice than in BALb/c mice and may therefore play a role in the etiology of the AKR leukemia.
在9个月的时间里，对易患白血病的AKR小鼠和不易患白血病的BALB/c小鼠胸腺中T细胞亚群的演变进行了比较。在AKR小鼠中，携带高浓度Thy 1抗原的胸腺激素敏感胸腺细胞急剧增加。虽然这些细胞在BALB/c小鼠中也随年龄增长而增加，但速度较慢。还比较了这两个品系胸腺细胞对刀豆蛋白A（Con A）的反应：AKR细胞的反应在7个月内降至显著水平以下，而BALB/c细胞在整个实验期间仍保持反应性。由于与胸腺激素制剂孵育后，这些与年龄相关的Thy 1抗原密度和Con A反应性变化可以逆转，因此得出结论，它们是胸腺激素分泌减少的结果，这种减少在AKR小鼠中比在BALB/c小鼠中更为明显，因此可能在AKR白血病的病因学中起作用。
