Korsager S, Sørensen H, Jensen O H, Falk J V
Scand J Rheumatol. 1981;10(3):174-6. doi: 10.3109/03009748109095293.
Auto-immunohaemolytic anaemia is a very unusual complication during long-term treatment with ibuprofen. In order to detect the haemolytic antibodies involved, serum and erythrocytes from 87 patients were investigated after continuous treatment with an average daily dose of 1337 mg ibuprofen for some 6-47 months. Eight patients showed a weak or medium-positive antiglobulin test result with polyspecific anti-human serum. With monospecific anti-human serum, complement C3c and/or C3d were detected on the surface of 8 patients' erythrocytes, but none had biochemical parameters indicating haemolysis. None of the 87 patients had IgG, IgM or IgA on their erythrocytes. The findings neither indicated haemolysis present nor early stages in any of the four types of drug-induced auto-immunohaemolytic anaemia. The frequency of a positive antinuclear factor test (ANF) among patients treated with ibuprofen did not differ from that of healthy subjects in the same age group. The type of haemolysis associated with ibuprofen is discussed, but available data do not permit any definite classification. It is concluded that ibuprofen is a safe drug which rarely causes haemolysis and does not seem to cause induction of ANF.
自身免疫性溶血性贫血是布洛芬长期治疗期间一种非常罕见的并发症。为了检测相关的溶血抗体，对87例患者连续平均每日服用1337毫克布洛芬约6至47个月后的血清和红细胞进行了研究。8例患者用多特异性抗人血清检测抗球蛋白试验结果呈弱阳性或中等阳性。用单特异性抗人血清检测发现，8例患者的红细胞表面存在补体C3c和/或C3d，但均无提示溶血的生化参数。87例患者的红细胞上均未检测到IgG、IgM或IgA。这些发现既未提示存在溶血，也未提示四种药物性自身免疫性溶血性贫血中的任何早期阶段。服用布洛芬的患者中抗核因子试验（ANF）阳性的频率与同年龄组健康受试者的频率无差异。文中讨论了与布洛芬相关的溶血类型，但现有数据无法进行明确分类。结论是布洛芬是一种安全的药物，很少引起溶血，似乎也不会导致ANF的诱导。
