Young L W, Yunis E J, Girdany B R, Sieber W K
AJR Am J Roentgenol. 1981 Oct;137(4):749-55. doi: 10.2214/ajr.137.4.749.
Four newborn infants with megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) were identified at Children's Hospital of Pittsburgh. These cases provide additional insight into the syndrome and broaden its spectrum. This report includes MMIHS in an infant boy, one long-term survivor, an apparently related complication of neonatal obstructive volvulus, evidence of small intestinal hypoperistalsis, and histopathologic findings as follows: (1) apparently increased numbers of ganglion cells in early biopsies and normal or even decreased numbers of ganglion cells in later biopsies probably due to bowel dilatation; and (2) in two of three infants at autopsy, there were many nerve trunks (a neuromalike layer in one), and there was elastosis of the urinary bladder.
匹兹堡儿童医院确诊了4例患有巨膀胱-微结肠-肠道蠕动功能减退综合征（MMIHS）的新生儿。这些病例为该综合征提供了更多见解，并拓宽了其范围。本报告包括一名患有MMIHS的男婴、一名长期存活者、新生儿梗阻性肠扭转的一种明显相关并发症、小肠蠕动功能减退的证据以及如下组织病理学发现：（1）早期活检中神经节细胞数量明显增加，后期活检中神经节细胞数量正常甚至减少，可能是由于肠扩张所致；（2）在三分之二的婴儿尸检中，有许多神经干（其中一例有类似神经瘤的一层），且膀胱有弹性组织变性。
