Temple C, Rose J D, Laster W R, Montgomery J A
Cancer Treat Rep. 1981 Nov-Dec;65(11-12):1117-9.
The isolation of citrovorum factor from a chemically prepared mixture of the L(+/-) diastereoisomers (leucovorin) is described. The natural diastereoisomer was at least twice as effective as leucovorin in reversing methotrexate toxicity in mice.
描述了从化学合成的L(+/-)非对映异构体混合物（亚叶酸钙）中分离出醛氢叶酸因子的方法。在逆转小鼠甲氨蝶呤毒性方面，天然非对映异构体的效果至少是亚叶酸钙的两倍。
