Effect of iodide on glucose, N-acetylglucosamine and leucine incorporation into acid-insoluble fraction of pig thyroid proteins in vitro.

The effect of KI on D-[1-14C]glucose and N-acetyl-D-[1-14C]glucosamine incorporation into thyroid proteins was studied in vitro. It was found that KI in a concentration of 0.1 mmol 1-1 had no effect on the incorporation of the sugars under study. However, under the same experimental conditions KI inhibited L-[1-14C]leucine incorporation into proteins. It is suggested that KI, appropriate concentrations, inhibits the synthesis of peptide chains but has no effect on the incorporation of sugars into proteins.