Dewille J W, Fraker P J, Romsos D R
J Nutr. 1981 Nov;111(11):2039-43. doi: 10.1093/jn/111.11.2039.
Effects of an essential fatty acid deficient (EFAD) [0% corn oil (CO)] diet and a diet high in polyunsaturated fatty acids [PUFA (50% CO)] on one aspect of in vivo T cell function [delayed-type hypersensitivity (DTH)] were assessed. After a 70-day feeding trial, DTH was reduced by 30% in mice fed the EFAD diet, but the response of mice fed the high PUFA diet equaled that of control mice fed a diet containing 13% CO. The time required for the EFAD diet to reduce DTH was 42 days. Although consumption of the EFAD diet reduced DTH, this reduction was rapidly reversed, within 7 days, by switching the EFAD mice to the control diet. These results indicate that :1) consumption of the EFAD diet reduces one aspect of in vivo T cell function (DTH), but the effect can be reversed by refeeding the control diet; and 2) a high PUFA diet does not adversely affect DTH.
评估了必需脂肪酸缺乏（EFAD）[0%玉米油（CO）]饮食和高多不饱和脂肪酸[PUFA（50%CO）]饮食对体内T细胞功能的一个方面[迟发型超敏反应（DTH）]的影响。经过70天的喂养试验，喂食EFAD饮食的小鼠的DTH降低了30%，但喂食高PUFA饮食的小鼠的反应与喂食含13%CO饮食的对照小鼠的反应相当。EFAD饮食降低DTH所需的时间为42天。虽然食用EFAD饮食会降低DTH，但通过将EFAD小鼠改喂对照饮食，这种降低在7天内迅速逆转。这些结果表明：1）食用EFAD饮食会降低体内T细胞功能的一个方面（DTH），但通过重新喂食对照饮食，这种影响可以逆转；2）高PUFA饮食不会对DTH产生不利影响。
