DeWille J W, Fraker P J, Romsos D R
J Nutr. 1979 Jun;109(6):1018-27. doi: 10.1093/jn/109.6.1018.
Six experiments were conducted to determine the influence of an essential fatty acid deficient diet (EFAD), and various levels of dietary polyunsaturated fatty acids, on humoral immunity in mice. The results indicated that: 1) Consumption of diets deficient in essential fatty acids (0% corn oil) significantly reduced the humoral response. This reduction was demonstrated after feeding the essential fatty acid deficient diet for only 28 days; and preceded the effects of essential fatty acid deficiency on growth or appearance. 2) Reduced antibody response was demonstrated against T-cell dependent and T-cell independent antigens, and in both primary and secondary responses of mice fed the essential fatty acid deficient diet. 3) After 56 days of feeding the EFAD diet (0% corn oil), mice switched to the control diet (13% corn oil) for 7 days demonstrated full recovery of the humoral response. 4) Diets containing various levels of polyunsaturated fatty acids (from 2 to 70% of energy from corn oil) did not adversely affect the humoral response. The results support the hypothesis that essential fatty acids play a crucial role in maintaining the functional integrity of humoral immunity.
进行了六项实验，以确定必需脂肪酸缺乏饮食（EFAD）以及不同水平的膳食多不饱和脂肪酸对小鼠体液免疫的影响。结果表明：1）食用缺乏必需脂肪酸的饮食（0%玉米油）会显著降低体液反应。仅在喂食必需脂肪酸缺乏饮食28天后就出现了这种降低；且早于必需脂肪酸缺乏对生长或外观的影响。2）在喂食必需脂肪酸缺乏饮食的小鼠的初次和二次反应中，针对T细胞依赖性和T细胞非依赖性抗原的抗体反应均降低。3）在喂食EFAD饮食（0%玉米油）56天后，改为喂食对照饮食（13%玉米油）7天的小鼠体液反应完全恢复。4）含有不同水平多不饱和脂肪酸（占玉米油能量的2%至70%）的饮食对体液反应没有不利影响。这些结果支持了必需脂肪酸在维持体液免疫功能完整性方面起关键作用的假说。
