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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Chapman R A, Leoty C

J Physiol. 1981 Aug;317:475-86. doi: 10.1113/jphysiol.1981.sp013837.

The effects of tetracaine on the membrane currents and contraction of isolated frog atrial trabeculae under voltage clamp has been investigated. 2. Tetracaine inhibits the slow inward current in a competitive way with a Ki of 0.13 mM, and the phasic component of the contractile response in a non-competitive manner with a Ki of 0.25 mM. 3. The tonic phase of contraction is little affects by tetracaine while the outward current is reduced. 4. The effects of tetracaine on contraction closely resemble those obtained previously with K contractures and further emphasize that two processes, both of which depend on the membrane potential, are involved in the initiation of contraction in amphibian heart. 5. The effect of tetracaine on the phasic tension would seem to be due to an inhibition of both the slow inward current and the release of Ca2+ from the sarcoplasmic reticulum.

研究了丁卡因在电压钳制下对离体蛙心房肌小梁膜电流和收缩的影响。2. 丁卡因以竞争性方式抑制慢内向电流，其抑制常数（Ki）为0.13 mM，并以非竞争性方式抑制收缩反应的时相成分，Ki为0.25 mM。3. 丁卡因对收缩的强直相影响很小，而外向电流减小。4. 丁卡因对收缩的影响与先前用钾挛缩得到的结果非常相似，进一步强调在两栖类心脏收缩起始过程中涉及两个均依赖于膜电位的过程。5. 丁卡因对时相张力的影响似乎是由于抑制了慢内向电流和肌浆网中Ca2+的释放。

Chapman R A, Leoty C

J Physiol. 1981 Aug;317:475-86. doi: 10.1113/jphysiol.1981.sp013837.

The effects of tetracaine on the membrane currents and contraction of isolated frog atrial trabeculae under voltage clamp has been investigated. 2. Tetracaine inhibits the slow inward current in a competitive way with a Ki of 0.13 mM, and the phasic component of the contractile response in a non-competitive manner with a Ki of 0.25 mM. 3. The tonic phase of contraction is little affects by tetracaine while the outward current is reduced. 4. The effects of tetracaine on contraction closely resemble those obtained previously with K contractures and further emphasize that two processes, both of which depend on the membrane potential, are involved in the initiation of contraction in amphibian heart. 5. The effect of tetracaine on the phasic tension would seem to be due to an inhibition of both the slow inward current and the release of Ca2+ from the sarcoplasmic reticulum.

研究了丁卡因在电压钳制下对离体蛙心房肌小梁膜电流和收缩的影响。2. 丁卡因以竞争性方式抑制慢内向电流，其抑制常数（Ki）为0.13 mM，并以非竞争性方式抑制收缩反应的时相成分，Ki为0.25 mM。3. 丁卡因对收缩的强直相影响很小，而外向电流减小。4. 丁卡因对收缩的影响与先前用钾挛缩得到的结果非常相似，进一步强调在两栖类心脏收缩起始过程中涉及两个均依赖于膜电位的过程。5. 丁卡因对时相张力的影响似乎是由于抑制了慢内向电流和肌浆网中Ca2+的释放。