Gohlke H, Gohlke-Bärwolf C, Stürzenhofecker P, Görnandt L, Ritter B, Reichelt M, Buchwalsky R, Schmuziger M, Roskamm H
Schweiz Med Wochenschr. 1981 Nov 7;111(45):1722-4.
To evaluate the effect of oral anticoagulant therapy on graft patency rate during the first 2 months after bypass surgery 174 patients were randomly assigned to treatment with phenprocoumon (89) or to a control group (85) starting on day 7 after bypass surgery. Until day 7 all patients received low dose heparin. There was no significant difference between the two groups with respect to age, sex distribution, number of vessels diseased, left ventricular enddiastolic pressure, preoperative exercise tolerance or number of grafts constructed per patient. All patients underwent angiographic evaluation 8 weeks after bypass surgery. Graft patency rate was 90.4% in the treatment group versus 83.6% in the control group (p less than 0.015). None of the grafts with a flow rate of greater than 90 ml/min was occluded 8 weeks after surgery. Oral anticoagulation improved the patency rate of grafts with a flow of less then 90 ml/min.
为评估口服抗凝治疗对搭桥手术后前2个月内移植血管通畅率的影响，174例患者在搭桥手术后第7天被随机分为苯丙香豆素治疗组（89例）和对照组（85例）。在第7天之前，所有患者均接受低剂量肝素治疗。两组在年龄、性别分布、病变血管数量、左心室舒张末期压力、术前运动耐量或每位患者构建的移植血管数量方面无显著差异。所有患者在搭桥手术后8周接受血管造影评估。治疗组的移植血管通畅率为90.4%，而对照组为83.6%（p<0.015）。术后8周，血流速度大于90 ml/min的移植血管均未闭塞。口服抗凝治疗提高了血流速度小于90 ml/min的移植血管的通畅率。
