自身抗独特型免疫对间质性肾炎的抑制作用。
Suppression of interstitial nephritis by auto-anti-idiotypic immunity.
作者信息
Neilson E G, Phillips M
出版信息
J Exp Med. 1982 Jan 1;155(1):179-89. doi: 10.1084/jem.155.1.179.
Abstract
Rats immunized with renal tubular antigens were protected from the development of interstitial nephritis by pretreatment with tubular antigen-reactive T lymphoblasts. Protected animals developed anti-idiotypic antibodies against idiotypes primarily within the antigen-binding region of monoclonal antitubular basement membrane antibodies. These studies extend the concept of auto-anti-idiotypic regulation to autoimmune disease, and they also provide an experimental basis for further efforts to develop biologically relevant mechanisms for attenuating the expression of other kidney diseases.
摘要
用肾小管抗原免疫的大鼠，通过用肾小管抗原反应性T淋巴母细胞预处理，可预防间质性肾炎的发生。受保护的动物产生了针对主要位于单克隆抗肾小管基底膜抗体抗原结合区内独特型的抗独特型抗体。这些研究将自身抗独特型调节的概念扩展到自身免疫性疾病，也为进一步努力开发减弱其他肾脏疾病表达的生物学相关机制提供了实验依据。
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