Rowley D A, Köhler H, Cowan J D
Contemp Top Immunobiol. 1980;9:205-30. doi: 10.1007/978-1-4615-9131-3_8.
The immune system is a complex network of molecules and cells specifically connected by the complementarity of receptors for antigen and receptors for receptors. The network includes multiple positive- and negative-feedback loops, which modulate the type, magnitude, and duration of responses. The great challenge is to devise ways to manipulate the system specifically to induce effective autoimmunity to cancer, to prevent allograft rejection, and to turn off undesirable responses in allergies and autoimmune diseases. Recognition of the immune system as a network helps to explain why these objectives are so difficult and why manipulation of multiple components to achieve desired regulation may be required. But presumably manipulation must be focused on connectivity between receptor for epitope and receptor for receptor to achieve a high degree of specific regulation.
免疫系统是一个由分子和细胞构成的复杂网络，这些分子和细胞通过抗原受体与受体的受体之间的互补性而特异性地连接在一起。该网络包含多个正反馈和负反馈回路，它们可调节免疫反应的类型、强度和持续时间。巨大的挑战在于设计出专门操纵该系统的方法，以诱导对癌症产生有效的自身免疫、防止同种异体移植排斥反应，并消除过敏和自身免疫性疾病中不良的免疫反应。将免疫系统视为一个网络有助于解释为何这些目标如此难以实现，以及为何可能需要操纵多个组成部分以实现所需的调节。但据推测，操纵必须聚焦于表位受体与受体的受体之间的连接性，以实现高度特异性的调节。
