Herath P R, Davidson G
Bull World Health Organ. 1981;59(3):383-6.
Malathion resistance in a population of Anopheles culicifacies from Maharashtra State in India, which also showed resistance to a number of other organophosphorus compounds, was found to be dominant in its expression. Most of the crossing and back-crossing results involving a susceptible population of the same species from Sri Lanka indicated the possible involvement of more than one genetic factor. The existence of such a broad spectrum of resistance, and experiments involving the use of the synergists triphenyl phosphate and piperonyl butoxide both suggest the presence of at least two mechanisms, one involving the specific carboxylesterase and the other the less specific mixed-function oxidase system.
在印度马哈拉施特拉邦的一群致倦库蚊中发现了对马拉硫磷的抗性，这群蚊子还对许多其他有机磷化合物表现出抗性，且这种抗性在表达上占主导地位。大多数涉及来自斯里兰卡的同一物种易感群体的杂交和回交结果表明，可能涉及不止一个遗传因素。如此广泛的抗性的存在，以及涉及使用增效剂磷酸三苯酯和胡椒基丁醚的实验都表明至少存在两种机制，一种涉及特定的羧酸酯酶，另一种涉及特异性较低的混合功能氧化酶系统。
