Tanabe S, Ochi T, Ono K
J Rheumatol. 1981 Nov-Dec;8(6):895-901.
Chronic polyarthritis was produced in inbred C3H/He mice after intraperitoneal (ip) administration of allogeneic thymocytes of inbred line BALB/c mice. The polyarthritis persisted more than 18 months without additional ip treatment. Histologically, synovial cell hyperplasia, granulation tissue formation, and inflammatory cell infiltration were seen. More than 6 months after the initial administration, range of motion of the affected joints was significantly restricted and the erosive destructions of joint cartilage were found roentgenographically. Thus, this experimentally induced arthritis proved to have many pathologic features in common with human rheumatoid arthritis.
通过腹腔注射近交系BALB/c小鼠的同种异体胸腺细胞，在近交系C3H/He小鼠中诱发了慢性多关节炎。在没有额外腹腔注射治疗的情况下，多关节炎持续了超过18个月。组织学检查可见滑膜细胞增生、肉芽组织形成和炎症细胞浸润。初次给药6个多月后，受影响关节的活动范围明显受限，X线检查发现关节软骨有侵蚀性破坏。因此，这种实验诱导的关节炎被证明具有许多与人类类风湿性关节炎相同的病理特征。
