Gannuszkina J W, Zyrnowa J G, Toropowa N G, Toporkowa T D, Alijewa L M
Neurol Neurochir Pol. 1981 Jul-Aug;15(4):387-91.
The per cent and absolute numbers of lymphocytes T and B were calculated in 37 patients with hereditary diseases of the nervous system (torsion dystonia, hepatolenticular degeneration, idiopathic tremor) and in 22 donors. Reactions of active and full spontaneous complement-induced formation of rosettes and B cell detection with surface immunoglobulin receptors were used for this purpose. In all hereditary diseases a reduction was found in the number of lymphocytes and a rise in the ability of the lymphocytes for complement-induced rosette formation. The obtained data should be evaluated, probably, as a secondary immunodeficiency state determined probably by metabolic disturbances playing an important role in the pathogenesis of hereditary nervous system diseases.
对37例神经系统遗传性疾病（扭转性肌张力障碍、肝豆状核变性、特发性震颤）患者及22名供血者的T淋巴细胞和B淋巴细胞的百分比及绝对数量进行了计算。为此采用了活性及完全自发补体诱导玫瑰花结形成反应以及用表面免疫球蛋白受体检测B细胞的方法。在所有遗传性疾病中均发现淋巴细胞数量减少，而淋巴细胞补体诱导玫瑰花结形成的能力增强。所获数据或许应被评估为一种继发性免疫缺陷状态，可能是由在遗传性神经系统疾病发病机制中起重要作用的代谢紊乱所决定的。
