Keene M, Hawke M, Barber H O, Farkashidy J
Arch Otolaryngol. 1982 Feb;108(2):65-70. doi: 10.1001/archotol.1982.00790500001001.
The temporal bone histopathological findings in a case of gentamicin sulfate-induced hearing loss and vertigo in an anephric patient undergoing hemodialysis are presented. A study of the sensory neuroepithelium of the cristae and maculae disclosed the presence of vacuoles with clubbing of the sensory cells. In the cochlea, loss of the innermost row of outer hair cells in the basal turn was the most prominent feature. These findings are discussed in light of reports of similar morphological changes in laboratory studies of gentamicin ototoxicity.
本文报告了一例在接受血液透析的无肾患者中，硫酸庆大霉素诱发听力丧失和眩晕的颞骨组织病理学研究结果。对嵴和斑的感觉神经上皮的研究发现，感觉细胞存在空泡化及棒状化现象。在耳蜗中，最显著的特征是基底转最内侧一排外毛细胞缺失。结合庆大霉素耳毒性实验室研究中类似形态学变化的报告，对这些发现进行了讨论。
