哮喘患者肺分泌物中的透明质酸。
Hyaluronic acid in the pulmonary secretions of patients with asthma.
作者信息
Sahu S, Lynn W S
出版信息
Biochem J. 1978 Aug 1;173(2):565-8. doi: 10.1042/bj1730565.
Abstract
Hyaluronic acid was the only glycosaminoglycan found in the pulmonary secretions of patients with asthma. The compound had a hexuronate/hexosamine molar ratio of about 1:1. Glucosamine constituted over 98% of the hexosamines, the remaining being galactosamine. The compound moved as a single spot with the mobility of standard hyaluronic acid on cellulose acetate electrophoresis, and this spot disappeared after digestion with testicular hyaluronidase. Even after extensive proteolysis and purification, the compound was associated with small amounts of protein, the major amino acids of which were aspartic acid, threonine, serine, glutamic acid, glycine and valine.
摘要
透明质酸是在哮喘患者肺分泌物中发现的唯一糖胺聚糖。该化合物的己糖醛酸/己糖胺摩尔比约为1:1。葡糖胺占己糖胺的98%以上，其余为半乳糖胺。该化合物在醋酸纤维素电泳上作为单一斑点移动，其迁移率与标准透明质酸相同，并且该斑点在用睾丸透明质酸酶消化后消失。即使经过广泛的蛋白水解和纯化，该化合物仍与少量蛋白质相关，其中主要氨基酸为天冬氨酸、苏氨酸、丝氨酸、谷氨酸、甘氨酸和缬氨酸。
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本文引用的文献
1
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Anal Biochem. 1962 Oct;4:330-4. doi: 10.1016/0003-2697(62)90095-7.
2
Studies on hyaluronic acid. II. The protein component(s) of rooster comb hyaluronic acid.
Biochim Biophys Acta. 1968 May 6;160(1):96-105. doi: 10.1016/0005-2795(68)90068-8.
3
Volume-controlled lung lavage in the treatment of asthma, bronchiectasis, and mucoviscidosis.容量控制肺灌洗治疗哮喘、支气管扩张症和黏液黏稠症。
Am Rev Respir Dis. 1971 May;103(5):651-65. doi: 10.1164/arrd.1971.103.5.651.
4
Improved method for electrophoretic separation and rapid quantitation of isomeric chondroitin sulfates on cellulose acetate strips.醋酸纤维素条带上硫酸软骨素异构体的电泳分离及快速定量的改进方法。
Anal Biochem. 1970 Sep;37(1):197-202. doi: 10.1016/0003-2697(70)90280-0.
5
Comparative biochemistry of chondroitin sulphate-proteins of cartilage and notochord.软骨和脊索硫酸软骨素蛋白的比较生物化学
Biochem J. 1971 Nov;125(1):37-46. doi: 10.1042/bj1250037.
6
The association of hyaluronic acid with protein in human synovial fluid.透明质酸与人体滑液中蛋白质的关联。
Biochim Biophys Acta. 1969 Nov 11;194(1):81-90. doi: 10.1016/0005-2795(69)90183-4.
7
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Fed Proc. 1966 May-Jun;25(3):1040-5.
8
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