三例同胞患毛细胞白血病：一种明显与 HLA 相关的疾病。

Hairy cell leukemia in three siblings: an apparent HLA-linked disease.

作者信息

Wylin R F, Greene M H, Palutke M, Khilanani P, Tabaczka P, Swiderski G

出版信息

Cancer. 1982 Feb 1;49(3):538-42. doi: 10.1002/1097-0142(19820201)49:3<538::aid-cncr2820490323>3.0.co;2-6.

DOI:10.1002/1097-0142(19820201)49:3<538::aid-cncr2820490323>3.0.co;2-6

Abstract

In a sibship of 11 adults the HLA haplotype A1, B7 occurred in four brothers, three of whom developed hairy cell leukemia (HCL) within a seven-year period. While this haplotype does not appear to occur with increased frequency in random cases of HCL, the fact that three cases of this uncommon and unique disorder occurred within one family and affected siblings with a common haplotype strongly suggests a genetic linkage.

摘要

在一个由11名成年人组成的家族中，HLA单倍型A1、B7出现在4名兄弟身上，其中3人在7年内患上了毛细胞白血病（HCL）。虽然这种单倍型在HCL的随机病例中似乎没有以更高的频率出现，但这种罕见且独特的疾病在一个家族中出现了3例，并且患病的兄弟姐妹具有共同的单倍型，这一事实强烈表明存在基因连锁关系。