Burns G F, Worman C P, Cawley J C
Clin Exp Immunol. 1980 Jan;39(1):76-82.
A new case of hairy-cell leukaemia (HCL) in which the hairy cells (HCs) formed spontaneous sheep erythrocyte (E) rosettes is described, and this E-rosette formation is shown to be an active process independent of surface immunoglobulin (SIg). Sequential studies with a panel of markers of this and of a case of HCL with T-cell features previously described from this laboratory show that both these cases, at certain times of study, possessed combined T- and B-cell features. Extensive follow-up study revealed wide fluctuations in the surface phenotype of peripheral blood (PB) mononuclear cells, while the total leucocyte count remained stable. At various times, the PB mononuclear cells showed the following phenotypes: E+SIg+gamma Fc+C3-, E-SIg-gamma Fc+C3-, E+SIg-gamma Fc+/-C3-, and the significance of these phenotypic changes is discussed. The importance of sequential studies with a panel of markers in the characterization of lymphoproliferative disorders is emphasized.
本文描述了一例新的毛细胞白血病（HCL），其毛细胞（HCs）形成自发绵羊红细胞（E）玫瑰花结，且这种E玫瑰花结形成是一个独立于表面免疫球蛋白（SIg）的活跃过程。使用本实验室先前描述的该病例及一例具有T细胞特征的HCL病例的一组标志物进行的序贯研究表明，在研究的某些时间，这两例病例均具有T细胞和B细胞联合特征。广泛的随访研究显示外周血（PB）单个核细胞表面表型波动很大，而白细胞总数保持稳定。在不同时间，PB单个核细胞表现出以下表型：E+SIg+γFc+C3-、E-SIg-γFc+C3-、E+SIg-γFc+/-C3-，并讨论了这些表型变化的意义。强调了使用一组标志物进行序贯研究在淋巴增殖性疾病特征描述中的重要性。
