Stein R S, Flexner J M, Collins R D
Cancer. 1982 Mar 1;49(5):846-9. doi: 10.1002/1097-0142(19820301)49:5<846::aid-cncr2820490504>3.0.co;2-p.
Twelve of 13 adult patients with acute lymphocytic leukemia, acute undifferentiated leukemia, or convoluted T-cell lymphoma (T-cell ALL) who were treated with Adriamycin, vincristine, and prednisone achieved a complete remission. An intensive consolidation regimen was administered. This regimen included Cytosine Arabinoside, L-asparaginase, and multiple courses of CHOP (cyclophosphamide, Adriamycin, vincristine, and prednisone). In addition, cranial irradiation and intrathecal methotrexate were administered. By actuarial estimate, 81% of previously untreated patients who achieved a complete remission will remain in remission for more than two years.
13例患有急性淋巴细胞白血病、急性未分化白血病或卷曲T细胞淋巴瘤（T细胞急性淋巴细胞白血病）的成年患者接受了阿霉素、长春新碱和泼尼松治疗，其中12例实现了完全缓解。给予了强化巩固方案。该方案包括阿糖胞苷、L-天冬酰胺酶以及多个疗程的CHOP（环磷酰胺、阿霉素、长春新碱和泼尼松）。此外，还进行了颅脑照射和鞘内注射甲氨蝶呤。据精算估计，81%实现完全缓解的既往未治疗患者将保持缓解状态超过两年。
