Morton B C, Smith F M, Ooi D S, Moti A R, Quevillon J, Nair R C, Neri L R, Meuffels M T, Keon W J
Clin Biochem. 1981 Dec;14(6):300-4. doi: 10.1016/s0009-9120(81)91026-2.
Frequent serum sampling of CK-MB and total CK levels was carried out in 100 patients during and up to 48 hours following aortocoronary bypass surgery. Using an ion exchange chromatography method for CK-MB determination, significantly higher serum CK-MB levels (peak 46.1 +/- 5.2 cf. 31.3 +/- 2.2 u/L), but not total CK levels were present 6 to 16 hours postoperatively in those with new Q waves in the ECG. Serum levels of CK-MB in those patients with uncomplicated surgery were defined. New post-operative Q waves were seen in only one half of cases with frankly abnormal CK-MB curves and seriously underestimated the incidence of perioperative infarction. Peak levels of CK-MB in patients with new Q waves occurred within 16 hours of surgery suggesting that infarction is usually an intraoperative or early post-operative event.
在100例接受主动脉冠状动脉搭桥手术的患者术中及术后48小时内，频繁采集血清样本检测肌酸激酶同工酶（CK-MB）和总肌酸激酶（CK）水平。采用离子交换色谱法测定CK-MB，心电图出现新Q波的患者术后6至16小时血清CK-MB水平显著升高（峰值为46.1±5.2对比31.3±2.2 U/L），但总CK水平未升高。定义了手术无并发症患者的血清CK-MB水平。仅有一半CK-MB曲线明显异常的病例出现术后新Q波，且严重低估了围手术期梗死的发生率。出现新Q波患者的CK-MB峰值出现在术后16小时内，提示梗死通常是术中或术后早期事件。
