Ström S, Mogensen L, Bendz R
Scand J Thorac Cardiovasc Surg. 1979;13(1):61-6. doi: 10.3109/14017437909101788.
Serum creatine kinase (CK) isoenzyme MB and total CK activity concentrations in 11 patients with acute myocardial infarction (AMI) were compared with the corresponding enzyme activities in 25 patients after coronary bypass surgery, not complicated clinically by AMI. Peak CK-MB occurred 2 +/- 0 (mean +/- SEM) hours after the end of surgery (mean duration of operation 6 hours), but 17 +/- 1 hours from the onset of symptoms in AMI. The plasma half"life for CK-MB was 11 +/- 1 hours under both conditions. Peak total CK was found after about 20 hours in both series of patients. Total CK half-life was 17 +/- 2 hours in AMI, but 30 +/- 3 hours following surgery. CK kinetics were thus different in these two situations, indicating different mechanisms for the elevations of serum CK-MB activity. In conclusion, the time course for the transient CK-MB elevation following bypass surgery should be considered in the diagnosis of peri operative infarction.
将11例急性心肌梗死（AMI）患者的血清肌酸激酶（CK）同工酶MB和总CK活性浓度，与25例冠状动脉搭桥手术后未出现临床并发症AMI的患者的相应酶活性进行了比较。CK-MB峰值在手术结束后2±0（平均值±标准误）小时出现（平均手术持续时间6小时），但在AMI中从症状发作起17±1小时出现。在两种情况下，CK-MB的血浆半衰期均为11±1小时。两组患者中总CK峰值均在约20小时后出现。AMI中总CK半衰期为17±2小时，但手术后为30±3小时。因此，这两种情况下CK动力学不同，表明血清CK-MB活性升高的机制不同。总之，在围手术期梗死的诊断中应考虑搭桥手术后CK-MB短暂升高的时间进程。
