Rabinowitz J L, Feldman E S, Weinberger A, Schumacher H R
J Clin Pharmacol. 1982 Jan;22(1):42-8. doi: 10.1002/j.1552-4604.1982.tb05706.x.
The local, articular, and systemic absorption of oral and topical salicylates was studied in dogs and humans using radioisotope techniques. Topical triethanolamine 14C-salicylate was found capable of percutaneous absorption into the knee joint and surrounding tissues. In dogs, topical salicylate application resulted in higher salicylate concentrations than oral aspirin in a number of tissues, despite lower blood levels. In patients with rheumatoid arthritis, intraarticular 14C-salicylate levels after triethanolamine 14C-salicylate cream were 60 per cent of those obtained with oral aspirin. Four of six patients reported equal improvement in local discomfort after oral and topical salicylates. A potential role for topical salicylate cream in the treatment of localized rheumatic disorders is suggested.
利用放射性同位素技术，在狗和人类身上研究了口服和局部使用水杨酸盐后的局部、关节及全身吸收情况。发现局部使用的三乙醇胺14C - 水杨酸盐能够经皮吸收进入膝关节及周围组织。在狗身上，尽管局部使用水杨酸盐后的血药浓度较低，但在许多组织中，其水杨酸盐浓度高于口服阿司匹林后的浓度。在类风湿性关节炎患者中，使用三乙醇胺14C - 水杨酸盐乳膏后关节内14C - 水杨酸盐水平为口服阿司匹林后水平的60%。六名患者中有四名报告称口服和局部使用水杨酸盐后局部不适均有同等程度改善。这表明局部使用水杨酸盐乳膏在治疗局部风湿性疾病方面可能具有一定作用。
